Contrary to what was previously thought, newborn immune T cells may have the ability to trigger an inflammatory response to bacteria, according to a new study. Although their immune system works very differently to that of adults, babies may still be able to mount a strong immune defense, finds the study.
Our immune system is made up of several different types of immune cells, including neutrophils which play an important role in the frontline defense against infection, and lymphocytes: B cells which produce antibodies, and T cells that target cells infected with viruses and microbes.
Up to now, it was generally believed that babies have an immature immune system that doesn't trigger the same inflammatory response normally seen in adults. Although babies need to protect themselves from the harmful pathogens they are exposed to from birth, it was thought that their T cells were suppressed to some extent to prevent inflammatory damage to the developing child. Sceptical of this notion, the King's-led study set out to characterize the properties of T cells, examining very small samples of blood in twenty-eight highly premature babies, as they developed over the first few weeks of life.
The team discovered that whilst T cells in newborn babies are largely different to those in adults, it is not because they are immunosuppressed; rather, they manufacture a potent anti-bacterial molecule known as IL8 that has not previously been considered a major product of T cells, and that activates neutrophils to attack the body's foreign invaders.
Dr Deena GibbonsDeena Gibbons, lead author in the Department of Immunobiology at King's College London, says: "We found that babies have an in-built anti-bacterial defense mechanism that works differently to adults, but nevertheless may be effective in protecting them. This may also be a mechanism by which the baby protects itself in the womb from infections of the mother. The next stage of our work will be to better understand the pathways that result in the immune cells of newborns being so different to those in adults."
This T cell activity could become a target for future treatments aimed at boosting the immune system of neonates in intensive care, where infection is a major risk for morbidity and mortality. Premature babies are also at serious risk of developing inflammatory diseases such as necrotising enterocolitis (NEC), where severe inflammation destroys tissues in the gut. NEC is the most common gastrointestinal surgical emergency in preterm babies, with mortality rates of around 15 to 30 per cent in the UK.
GMT 13:50 2018 Tuesday ,30 October
Emergency surgery saves life of touristGMT 13:20 2018 Monday ,29 October
National campaign to raise awareness of breast cancerGMT 14:34 2018 Friday ,19 October
Birth spacing "improving health of Omani women"GMT 15:35 2018 Thursday ,11 October
Russia to discuss issue of biological labs near its bordersGMT 16:14 2018 Saturday ,29 September
Premier Khalifa bin Salman congratulated by health ministerGMT 16:10 2018 Saturday ,29 September
Bahrain to host Dermatology, Laser and Aesthetics ConferenceGMT 12:44 2018 Friday ,28 September
EU proposes €40 million for UNRWA to keep health clinics openGMT 07:46 2018 Wednesday ,26 September
HRH Premier to address UN high-level health meetingsMaintained and developed by Arabs Today Group SAL.
All rights reserved to Arab Today Media Group 2021 ©
Maintained and developed by Arabs Today Group SAL.
All rights reserved to Arab Today Media Group 2021 ©
Send your comments
Your comment as a visitor