Cells in the human body are constantly being exposed to stress from environmental chemicals or errors in routine cellular processes. While stress can cause damage, it can also provide the stimulus for undoing the damage. New research by a team of scientists at the University of Rochester has unveiled an important new mechanism that allows cells to recognize when they are under stress and prime the DNA repair machinery to respond to the threat of damage. Their findings will be published Friday in journal Science. The scientists, led by biologists Vera Gorbunova and Andrei Seluanov, focused on the most dangerous type of DNA damage double strand breaks. Unrepaired, this type of damage can lead to premature aging and cancer. They studied how oxidative stress affects efficiency of DNA repair. Oxidative stress occurs when the body is unable to neutralize the highly-reactive molecules, which are typically produced during routine cellular activities. The research team found that human cells undergoing oxidative stress synthesized more of a protein called SIRT6. By increasing SIRT6 levels, cells were able to stimulate their ability to repair double strand breaks. When the cells were treated with a drug that inactivated SIRT6, DNA repair came to a halt, thus confirming the role of SIRT6 in DNA repair. Gorbunova notes that the SIRT6 protein is structurally related to another protein, SIR2, which has been shown to extend lifespan in multiple model organisms. "SIRT6 also affects DNA repair when there is no oxidative stress," explains Gorbunova. "It's just that the effect is magnified when the cells are challenged with even small amounts of oxidative stress." SIRT6 allows the cells to be economical with their resources, priming the repair enzymes only when there is damage that needs to be repaired. Thus SIRT6 may be a master regulator that coordinates stress and DNA repair activities, according to Gorbunova.
GMT 13:50 2018 Tuesday ,30 October
Emergency surgery saves life of touristGMT 13:20 2018 Monday ,29 October
National campaign to raise awareness of breast cancerGMT 14:34 2018 Friday ,19 October
Birth spacing "improving health of Omani women"GMT 15:35 2018 Thursday ,11 October
Russia to discuss issue of biological labs near its bordersGMT 16:14 2018 Saturday ,29 September
Premier Khalifa bin Salman congratulated by health ministerGMT 16:10 2018 Saturday ,29 September
Bahrain to host Dermatology, Laser and Aesthetics ConferenceGMT 12:44 2018 Friday ,28 September
EU proposes €40 million for UNRWA to keep health clinics openGMT 07:46 2018 Wednesday ,26 September
HRH Premier to address UN high-level health meetingsMaintained and developed by Arabs Today Group SAL.
All rights reserved to Arab Today Media Group 2021 ©
Maintained and developed by Arabs Today Group SAL.
All rights reserved to Arab Today Media Group 2021 ©
Send your comments
Your comment as a visitor