why miracle diet could be key to beat epileptic seizures
Last Updated : GMT 06:49:16
Arab Today, arab today
Arab Today, arab today
Last Updated : GMT 06:49:16
Arab Today, arab today

Why `miracle diet` could be key to beat epileptic seizures

Arab Today, arab today

Arab Today, arab today Why `miracle diet` could be key to beat epileptic seizures

Washington - Arabstoday

For decades, neurologists have known that a high-fat, low-carbohydrate diet can reduce drug resistant epileptic seizures. But so far, how the diet worked, and why, was a mystery. Now, a new study has unraveled a link between a protein that can modify cellular metabolism in the brain and susceptibility of an epileptic seizure. Epilepsy is a disorder which is characterized by seizures, unpredictable and abnormal bursts of electrical activity in the brain. Some cases of epilepsy are resistant to the traditional drug treatments but can be improved by a "ketogenic" diet. Ketogenic diet, which is very low in sugars and high in fat, forces neurons to switch from their customary fuel of glucose to a type of fat byproduct called a ketone body. "The potent effect of increased ketone metabolism on human epilepsy points to a link between fuel utilization and neuronal excitability," said Nika N. Danial, from Dana-Farber Cancer Institute and Harvard Medical School. "However, the molecular underpinnings of this link are not fully understood," she said. To study as to how the altered metabolism might protect the brain from seizures, Danial, co-senior author Gary Yellen, and their colleagues explored the role of a protein called BAD (BCL-2-associated Agonist of Cell Death), which modulates glucose metabolism in multiple types of cells. This allowed examination of altered fuel metabolism without radical dietary manipulations, which can have complex and at times adverse systemic effects. The researchers found that modifications to BAD that reduced glucose metabolism and increased ketone body metabolism in the brain were associated with a decrease in seizure susceptibility. They went on to show that this decrease in seizure susceptibility was due to increased activity of an ion channel that dampens neuronal excitability. Compiled together, the findings identify `BAD' as a regulator of fuel metabolism in the brain and implicate this protein in the regulation of seizures. "BAD''s capacity to modulate energy metabolism in the brain, independent of dietary manipulation, makes it an attractive candidate for metabolic control of seizures," said Yellen. "Small molecules modeled after BAD variants may help uncover new therapeutic targets to treat epileptic disorders," he added. This study has been published by Cell Press in the journal Neuron. (ANI)

arabstoday
arabstoday

Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

why miracle diet could be key to beat epileptic seizures why miracle diet could be key to beat epileptic seizures

 



Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

why miracle diet could be key to beat epileptic seizures why miracle diet could be key to beat epileptic seizures

 



GMT 11:50 2017 Wednesday ,22 February

2 Additional N. Koreans Identified as Being Linked

GMT 17:39 2017 Saturday ,02 September

Minister underlines support for OPEC cut deal

GMT 03:39 2017 Sunday ,24 September

6 arrested over extremist recruitment in Russia

GMT 02:26 2017 Thursday ,23 November

Al Hariri returns to Lebanon and abandons resignation

GMT 21:33 2017 Friday ,29 September

Official underlines economic improvement

GMT 04:36 2017 Wednesday ,14 June

EU seeks post-Brexit powers over London finance

GMT 17:59 2017 Friday ,20 October

In Syria, student dreams shattered by war

GMT 11:30 2017 Thursday ,16 February

Four dynamic ways to style your family’s portraits

GMT 13:54 2015 Saturday ,24 October

Kuznetsova ends title drought at Kremlin Cup
Arab Today, arab today
 
 Arab Today Facebook,arab today facebook  Arab Today Twitter,arab today twitter Arab Today Rss,arab today rss  Arab Today Youtube,arab today youtube  Arab Today Youtube,arab today youtube

Maintained and developed by Arabs Today Group SAL.
All rights reserved to Arab Today Media Group 2025 ©

Maintained and developed by Arabs Today Group SAL.
All rights reserved to Arab Today Media Group 2025 ©

arabstoday arabstoday arabstoday arabstoday
arabstoday arabstoday arabstoday
arabstoday
بناية النخيل - رأس النبع _ خلف السفارة الفرنسية _بيروت - لبنان
arabstoday, Arabstoday, Arabstoday