Rome - AP
Cristiano Ronaldo became the first player to net 400 goals across Europe's top five leagues.
It wasn't enough on Saturday to maintain Juventus' perfect start to the season.
Ronaldo, who has been accused of rape in a civil lawsuit in the United States, scored in the 1-1 draw against Genoa. It was his fifth Serie A goal in nine matches.
Ronaldo has 311 goals in La Liga for Real Madrid, and 84 in the English Premier League for Manchester United.
Juventus won all of its previous 10 matches across Serie A and the Champions League.
Ronaldo had last weekend off while Juventus was idle during the international break. Normally the star of his national team, he was left off Portugal's squad.
Ronaldo started brightly: A header came off the crossbar and he drew a save from Genoa goalkeeper Ionut Radu in the opening 14 minutes.
Less than five minutes later, he scored. There was a miscommunication between Radu and his defender on Joao Cancelo's cross from the left, allowing Ronaldo a simple tap-in at the far post.
Genoa hadn't scored at Juventus since January 2013, but this time it featured Krzysztof Piatek, who scored in each of their previous seven Serie A matches and had a league-best nine goals.
However, it wasn't the Poland forward who netted the equalizer but Daniel Bessa with a header in the 67th minute as the Juventus defense was caught napping when Christian Kouame managed to keep the ball in before whipping in a cross.
It was a memorable first match back in charge for Ivan Juric, who returned to Genoa for his third spell as coach.
MOMENT OF MADNESS
Roma fell to a surprise 2-0 defeat at home to 10-man Spal, which won at the Stadio Olimpico for the first time in Serie A in 53 years.
Roma went into the international break with four straight wins in all competitions while Spal had lost its last four.
However, the visitors took the lead shortly before halftime when Andrea Petagna converted a penalty after Manuel Lazzari was fouled by Luca Pellegrini.
Spal doubled its advantage 11 minutes after the break as Kevin Bonifazi headed in a corner at the near post.
Spal goalkeeper Vanja Milinkovic-Savic - the younger brother of Lazio midfielder Sergej - did brilliantly to fingertip Pellegrini's effort onto the bar but swiftly went from hero to villain.
Milinkovic-Savic was booked for time-wasting and he received a second yellow card seconds later for petulantly throwing the ball away, leaving Spal with 10 men for the final 15 minutes.
However, it clung on for its first win at Roma in the top flight since 1965.