Japan's Nikkei stock index fell Tuesday for the first time in three days amid concern over the yen's appreciation, as well as losses in US shares that drove the Dow to a three-week low overnight. 
The 225-issue Nikkei Stock Average fell 244.32 points, or 1.47% from Monday to close at 16,391.45. 
The broader Topix index of all First Section issues on the Tokyo Stock Exchange finished 21.63 points, or 1.64% lower at 1,300.20. 
Decliners were led by mining, bank and nonferrous metal issues. 
The day's turnover was about 2,080.7 billion yen (around 20.31 billion US dollars).